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2020年9月新版女性生殖器官肿瘤分类正式发布,过去的六年中,影响肿瘤分类的关键性分子改变不断被发现,形态学-分子分类的整合已慢慢取代女性生殖器肿瘤中原来的单纯的形态学分类,并对诊断和治疗产生影响。本文将对比2020版及2014版WHO女性生殖器官肿瘤分类,重点介绍新版分类中的主要变化。
Abstract:[1]WHO Classification of Tumours:Female genital tumours[M].Lyon(France):International Agency for Research on Cancer;2020.(WHO classification of tumours series,5th ed).https://publications.iarc.fr/592.
[2]Kurman R,Carcangiu ML,Herrington CS,et al.WHOclassification of tumors of female reproductive organs[M].Lyon:IARC Publications,2014.
[3]Cree IA,Deans Z,Ligtenberg N,et al.Guidance for laboratories performing molecular pathology for cancer patients[J].JClin Pathol,2014,67:923-931.
[4]Singer G,Shih Ie M,Truskinovsky A,et al.Mutational analysis of K-ras segregates ovarian serous carcinomas into two types:invasive MPSC(low-grade tumor) and conventional serous carcinoma(high-grade tumor)[J].Int J Gynecol Pathol,2003,22(1):37-41.
[5]Singer G,St9hrR,Cope L,et al.Patterns of p53 mutations separateovarian serous borderline tumors and low-and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis:a mutational analysis with immunohistochemical correlation[J].Am J Surg Pathol,2005,29(2):218-224.
[6]Malpica A,Deavers MT,Tornos C,et al.Interobserver and intraobserver variability of a two-tier system for grading ovarianserous carcinoma[J].Am J Surg Pathol,2007,31(8):1168-1174.
[7]Talhouk A,Mc Conechy MK,Leung S,et al.A clinically applicable molecular-based classification for endometrial cancers[J].Br J Cancer,2015,113(2):299-310.
[8]Stelloo E,Nout RA,Osse EM,et al.Improved risk assessment by integrating molecular and clinicopathological factors in earlystage endometrial cancer-combined analysis of the PORTECcohorts[J].Clin Cancer Res,2016,22(16):4215-4224.
[9]Stolnicu S,Barsan I,Hoang L,et al.International endocervical adenocarcinoma criteria and classification(IECC):a new pathogenetic classification for invasive adenocarcinomas of the endocervix[J].Am J Surg P athol,2018,42(2):214-226.
[10]Cree IA,Foss AJ,Luthert,PJ.Undefined high-power fields[J].Lancet,1996,347(8996):273-274.
基本信息:
中图分类号:R737.3
引用信息:
[1]宋艳,刘爱军.第五版WHO女性生殖器官肿瘤分类解读[J].诊断病理学杂志,2021,28(01):1-4.