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细环病毒（TTV）是一种具有高度变异性的环状单链DNA病毒，具有高流行率、基因组高度异质性以及宿主泛嗜性等特点，其复制机制、感染致病机制和遗传变异原因尚未完全阐明。新近研究证实，TTV复制水平与宿主免疫状态密切相关，可作为器官移植、HIV感染、肿瘤免疫治疗、自身免疫疾病以及疫苗应答中的免疫监测生物标志物。本文就TTV的病毒结构、流行病学特征、与宿主免疫相互作用机制及检测技术研究进展进行综述，为TTV 的基础研究与临床转化应用提供参考。
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基本信息:
中图分类号:R373
引用信息:
[1]刘静璇,刘丹,赵彬,等.TTV病毒的研究进展及其检测的临床意义[J].诊断病理学杂志().
基金信息:
首都儿科研究所引进人才科研启动基金（HX202553）
2026-08-19
2026-08-19
2026-08-19