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目的 分析子宫内膜癌（EC）组织中核因子-κB（NF-κB）、信号转导与转录激活因子3（STAT3）表达及其与EC病理特征的关系。方法 回顾性分析沧州市人民医院2023年2月至2024年3月收治的101例EC患者的临床资料，选取101例EC组织石蜡标本和距离癌组织边缘 5cm 的癌旁组织石蜡标本作为研究对象。采用免疫组织化学法（IHC）检测NF-κB、STAT3，分析不同组织中NF-κB、STAT3表达情况及其与EC组织临床病理特征的关系；并采用Pearson相关性分析NF-κB、STAT3的表达量相关性。结果 EC组NF-κB、STAT3阳性表达率分别为60.40%、71.29%，癌旁正常组织组分别为21.78%、30.69%，EC组NF-κB、STAT3阳性表达率明显高于癌旁正常组织组（P ＜0.05）。低分化、Ⅲ～Ⅳ期、有淋巴结转移及肌层浸润深度≥1/2患者NF-κB、STAT3阳性表达率明显高于高中分化、Ⅰ～Ⅱ期、无淋巴结转移者及肌层浸润深度＜1/2者（P＜0.05）。但上述因子表达在患者年龄、肿瘤直径及组织学类型中比较均无统计学意义（P＞0.05）。Pearson相关性分析结果显示，在EC中NF-κB与STAT3的表达量呈正相关（r = 0.582，P ＜0.05）。结论 NF-κB、STAT3在EC组织中阳性表达率较高，随疾病进展NF-κB、STAT3表达升高，二者可能共同参与了EC发展及转移过程，可作为评估EC患者肿瘤侵袭性的参考指标。
Abstract：Objective To analyze the expression of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) in endometrial cancer (EC) tissues and their relationship with pathological features of EC. Methods Clinical data of 101 EC patients admitted to Cangzhou People's Hospital from February 2023 to March 2024 were retrospectively analyzed. Paraffin-embedded specimens of EC tissues and adjacent normal tissues (5 cm from the tumor margin) were collected. Immunohistochemistry was employed to detect NF-κB and STAT3 expression. The expression levels of NF-κB and STAT3 in different tissues and their associations with clinicopathological characteristics were analyzed. Pearson correlation analysis was used to evaluate the correlation between NF-κB and STAT3 expression levels. Results The positive expression rates of NF-κB and STAT3 in the EC group were 60.40% and 71.29%， respectively， significantly higher than those in the adjacent normal tissue group (21.78% and 30.69%， respectively; P < 0.05). Patients with poor differentiation， stage III–IV disease， lymph node metastasis， and depth of myometrial invasion ≥ 1/2 exhibited significantly higher positive expression rates of NF-κB and STAT3 compared to those with moderate/well differentiation， stage I–II disease， without lymph node metastasis， and depth of myometrial invasion < 1/2 (P < 0.05). No significant associations were observed between NF-κB or STAT3 expression and age， tumor diameter， or histological type (P > 0.05). Pearson correlation analysis revealed a positive correlation between NF-κB and STAT3 expression levels in EC tissues ( r = 0.582， P < 0.05). Conclusion NF-κB and STAT3 are highly expressed in EC tissues， and their expression levels increase with disease progression. Both proteins may be jointly involved in the development and metastasis of EC， serving as potential reference indicators for assessing tumor aggressiveness in EC patients.
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基本信息:
中图分类号:R737.33
引用信息:
[1]张喆,左学骞,赵海波,等.子宫内膜癌组织中NF-κB、STAT3蛋白表达及其与病理特征的关系[J].诊断病理学杂志().
基金信息:
2023年度河北省医学科学研究课题计划（20232087）
2026-09-08
2026-09-08
2026-09-08